THE BEST SIDE OF METHADONE PRESCRIPTION EXAMPLE

[sixty one] Like many other cardiotoxic drugs, methadone blocks the hERG K+ channel. The two enantiomers of methadone inhibit hERG channels with different potency. Dextromethadone, that's less strong being an opioid, is more powerful at blocking the hERG channel with an IC50 of ~twelve μM. Levomethadone incorporates a lower affinity, with an IC50